Hemoglobin Is a Co-Factor of Human Trypanosome Lytic Factor
نویسندگان
چکیده
منابع مشابه
Hemoglobin Is a Co-Factor of Human Trypanosome Lytic Factor
Trypanosome lytic factor (TLF) is a high-density lipoprotein (HDL) subclass providing innate protection to humans against infection by the protozoan parasite Trypanosoma brucei brucei. Two primate-specific plasma proteins, haptoglobin-related protein (Hpr) and apolipoprotein L-1 (ApoL-1), have been proposed to kill T. b. brucei both singularly or when co-assembled into the same HDL. To better u...
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Natural resistance of humans to the cattle pathogen Trypanosoma brucei brucei has been attributed to the presence in human serum of nonimmune factors that lyse the parasite. Normal human serum contains two trypanosome lytic factors (TLFs). TLF1 is a 500-kDa lipoprotein, which is reported to contain apolipoprotein A-I (apoA-I), haptoglobin-related protein (Hpr), hemoglobin, paraoxonase, and apoA...
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متن کاملThe trypanosome lytic factor of human serum and the molecular basis of sleeping sickness.
Trypanosoma brucei brucei infects a wide range of mammals but is unable to infect humans because this subspecies is lysed by normal human serum (NHS). The trypanosome lytic factor is associated with High Density Lipoproteins (HDLs). Several HDL-associated components have been proposed as candidate lytic factors, and contradictory hypotheses concerning the mechanism of lysis have been suggested....
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2007
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.0030129